National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


ISSN 2313-4607 (Online)
ISSN 2304-8336 (Print)

Problems of Radiation Medicine and Radiobiology

  
 

   

O. V. Nosach, E. O. Sarkissova, S. M. Alyokhina, O. Ya. Pleskach, O. M. Litvinets,
L. M. Ovsyannikova, A. A. Chumak

State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine

SUBCLINICAL INFLAMMATION IN NON-ALCOHOLIC FATTY LIVER DISEASE AT THE REMOTE PERIOD AFTER THE CHORNOBYL ACCIDENT

Objective: to evaluate the parameters of inflammatory reaction and oxidative stress in patients with non-alcoholic fatty liver disease (NAFLD) in the remote period after the influence of the Chornobyl accident factors.
Materials and methods. Eighty two patients with NAFLD who had been exposed to ionizing radiation as a result of the Chornobyl accident and have concomitant cardiovascular pathology were examined. Hematological parameters and the level of highly sensitive C-reactive protein (hsCRP) were determined, and the content of products of oxidative modification of lipids and proteins was evaluated.
Results. Activation of the processes of oxidative modification of lipids and proteins was observed in most patients with NAFLD. According to the level of hsCRP, the presence of subclinical inflammation and the risk of developing complicated cardiovascular pathology was found in 58 % of patients with NAFLD. The neutrophil / lymphocyte ratio correlates positively with hsCRP and can be used as an available routine clinical marker for selection among patients with NAFLD persons with increased risk of cardiovascular complications.
Conclusions. HsCRP, oxidative modification products of lipids and proteins, ESR, and leukograms should be used to assess the degree of systemic inflammation in people affected by the Chornobyl accident, suffering NAFLD with concomitant cardiovascular disease.
Key words: non-alcoholic fatty liver disease, chronic subclinical inflammation, Chornobyl accident.

Problems of Radiation Medicine and Radiobiology.
2021;26:437-448. doi: 10.33145/2304-8336-2021-26-437-448

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