National Academy of Medical Sciences of Ukraine
State Institution "The National Research Center for Radiation Medicine"


ISSN 2313-4607 (Online)
ISSN 2304-8336 (Print)

Problems of Radiation Medicine and Radiobiology

  
 

   

D. . Bilyi, O. M. Nastina, G. V. Sydorenko, N. I. Bilous, N. V. Kursina, G. V. Pleskach,
O. D. Bazyka, O. M. Makarevysh, O. S. Kovaliov, A. A. Chumak, I. V. Abramenko

State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova str., Kyiv, 04050, Ukraine

GENDER DISPARITIES OF CIRCULATORY DISEASE PROGRESS IN THE CHORNOBYL ACCIDENT CLEAN-UP WORKERS AND PHOS-PHODIESTERASE 4D GENE rs966221 POLYMORPHISM

Objective. Evaluation of the hypertensive disease (HD) and coronary heart disease (CHD) progress in the Chornobyl NPP (ChNPP) accident clean-up workers (ACUW) and persons not exposed to ionizing radiation depending on gender and genotype of the phosphodiesterase 4D (PDE4D) gene rs966221 polymorphism.
Materials and methods. There were male ACUW (ACUWm; n=515) and female ACUW (ACUWf; n=145) involved in the study since 2013 till 2018. Participation in the clean-up works took place in 19861987. The control group included male (CGm; n=162) and female (CGf; n=120) persons not exposed to ionizing radiation. All study subjects have had neither signs nor symptoms of HD or CHD before the ChNPP accident.
Results. Review of the Kaplan-Meier survival tables indicated that according to median survival the HD emerged in ACUWm and ACUWf in a younger age (47.5 0.6 and 50.7 0.7 years old, respectively) vs. CGm or CGf (54.9 1.1 and 54.4 1.1 years, respectively). The same was true for CHD where the median values were (56.8 0.5), (61.2 0.8), (61.6 1.0) and (64.2 1.4) years respectively. Review of cumulative incidence of HD and CHD revealed no association of the PDE4D gene rs966221 polymorphism with the diseases of concern. The TT gene carrier state compared to the CC or CT genes features an increased risk of myocardial infarction (MI) 2.9 times in ACUWm, 4-fold in CGm, and 5.5 times in CGf (p < 0.05). No any gene carrier state was associated with MI in the ACUWf. Onset of menopause was followed by an increase in HD incidence vs. males.
Conclusions. The male and female ChNPP ACUW were developing HD and CAD at a younger age compared with corresponding non-irradiated control. In male ACUW in comparison with female ACUW the cumulative morbidity rate for MI was higher in any age range, whereas for CAD it was higher from 23 to 74 years, and for HD from 25 to 53 years of age. In male and female ACUW as well as in non-irradiated control the HD developed much earlier than CHD. The carrier state of TT genotype of PDE4D gene rs966221 polymorphism increases the risk of MI in males of all ages, in the non-irradiated controls it is increased in 65 years for men and in 60 years for women. No data on association of the genotype of the described gene polymorphism with MI were found in female ACUW.
Key words: Chornobyl accident clean-up workers, ionizing radiation, arterial hypertension, coronary heart disease, myocardial infarction, gender disparities, PDE4D gene rs966221 polymorphism.

Problems of radiation medicine and radiobiology.
2018;23:263_282. doi: 10.33145/2304-8336-2018-23-263-282.

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