V. V. Paramonov
Cherkasy Regional Oncology Center, Mendeleev str., 7, Cherkasy, 18009, Ukraine
The incidence of hematological neoplasms morbidity on radiation-contaminated territories in Cherkasy region
Objective. The main goal was to analyze the incidence of the morbidity in 1980, 1989, 2001, 2014 years and the structures of the absolute number of hematopoietic and lymphoid neoplasms cases during the period 1980–2014 on radiation-contaminated and not contaminated territories in Cherkasy region.
Materials and methods. The epidemiological indecies of hematological neoplasms were analyzed on radiation-contaminated and not contaminated territories in Cherkasy region during the period from 1980 to 2014. Referring the territory in Cherkasy region to radiation-contaminated is based on settlements dosimetry certification of Ukraine after the Chornobyl accident. 63 settlements were enrolled to radiation-contaminated areas in Cherkasy region and 11 settlements assigned as not contaminated areas.
Results. The first positions in the list of the hematological neoplasms structure and frequency among new cases during 1980–2014 on not contaminated territories in Cherkasy region occupied by lymphoid leukemia, Hodgkin’s lymphoma and myeloid leukemia and on the radiation-contaminated territories – chronic, acute lymphoid and myeloid leukemia and lymphoma, diffuse large cell lymphoma. In the structure of hematological neoplasms recorded on the contaminated territories in Cherkasy region, there is a smaller proportion of Hodgkin’s lymphoma cases (C81) than 0.84-fold (RR = 0.84; 95 % CI = 0.75–0.93) and more than 1.15 times (RR = 1.15; 95 % CI = 1.02–1.30) other unspecified malignant lymphoid and hematopoietic neoplasms. In 2001 on the radiation-contaminated territories in Cherkasy region increase the incidence of acute and chronic myeloid leukemia in 2.46 times (p = 0.024) observed compared to non contaminated areas there (5.30 per 100 000, 95% CI = 3.03–8.33 versus 2.15 per 100,000, 95 % CI = 0.66–3.64). It was calculated that RR of acute and chronic myeloid leukemia (C92) in 2001 on radiation-contaminated areas in Cherkasy region is 1.40 (95 % CI = 1.12–1.17) and Hodgkin’s lymphoma (C81) on conditionally clean areas Cherkasy region – 1.70 (95 % CI = 1.36–2.12).
Key words: Cherkasy region, radiation-contaminated areas, tumors of hematopoietic and lymphoid system.
Problems of radiation medicine and radiobiology. 2017;22:428–449.
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